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Friday, April 17, 2020 | History

3 edition of B cells and autoantibody production in autoimmune diseases found in the catalog.

B cells and autoantibody production in autoimmune diseases

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Published by Springer, R.G. Landes in New York, London, Austin, Tex .
Written in English


Edition Notes

StatementChristian Boitard.
SeriesMedical intelligence unit
The Physical Object
Paginationvi,273p. 19figs.11tabs. ;
Number of Pages273
ID Numbers
Open LibraryOL17953684M
ISBN 103540604448

  Adaptive immunity describes slower immune responses, including the production of immune cells that produce specific antibodies to target and remove a particular microorganism [1]. In cell-mediated immunity, T lymphocytes are produced that are conditioned to eliminate intracellular pathogens (viruses and bacteria) [4]. Early B cell development and commitment to the B cell lineage occurs in the foetal liver prenatally, before continuing in the bone marrow throughout life. B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin (Ig) directed against invasive pathogens (typically known as antibodies).   Autoimmune diseases are caused by a dysfunctional immune response in which the body creates autoantibodies that attack the individual’s own proteins. One of the common targets in autoimmune therapy are B cells, which are responsible for the production of autoantibodies.   B cells have a fundamental role in the pathogenesis of various autoimmune neurological disorders, not only as precursors of antibody-producing cells, but also as important regulators of the T-cell.


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B cells and autoantibody production in autoimmune diseases by Christian Boitard Download PDF EPUB FB2

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology.

The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled. The B1 B-cell equivalent subset and its role in human autoimmune diseases, however, remain to be delineated.

Although there is an increase in CD5 + B cells in both SLE and pSS, these cells may represent an expended population of pre-naïve conventional B2 cells and not the human equivalent of B1 cells [6].Cited by:   Having been considered for a long time as a T cell-dominated disease, based on the T cell-driven animal model of experimental autoimmune encephalomyelitis (EAE), B cells have moved into focus over the recent years, inspired by the success of B cell-directed therapies [1,9,10] and emerging experimental evidence of direct B cell involvement extending far beyond their role as mere antibody-producing cells Cited by: Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell.

The use of monoclonal antibodies that specifically target B cells, in particular anti-CD20 and ant-BLyS antibodies, have demonstrated the efficacy of this approach for the treatment of human autoimmunity, but questions remain open, how these B cell-targeted therapies work and why in certain autoimmune diseases clinical benefit is unpredictably : Thomas H.

Winkler, Reinhard E. Voll. Development of high-affinity antibodies requires cognate B cell/T cell interactions to initiate and sustain the GC. Somatically mutated autoantibodies in autoimmune disease are thought to be derived B cells and autoantibody production in autoimmune diseases book T cell–dependent pathways, especially because the presence of autoantibodies is often correlated with the presence of specific HLA alleles (20, 21).

(B) Activated CD4 T cells play a central role in inflammatory responses in the synovial membrane, including autoantibody production by plasma cells, secretion of inflammatory cytokines by macrophages and synoviocytes, bone erosion by osteoclasts and inhibition of collagen secretion by : Patricia Castro-Sánchez, Pedro Roda-Navarro.

Immune complexes are often associated with systemic autoimmune disease. Autoreactive B and T cells persist in normal subjects but in disease are selected by autoantigen in the production of autoimmune responses. Microbial cross-reaching antigens and cytokine dysregulation can lead to Size: 1MB.

“Islet autoantibody” is a generic term for any one of a group of autoantibodies that are directed against the islets of Langerhans or, in some circumstances, are directed specifically against autoantigens of the insulin-secreting β cells.

β-Cell death that causes type 1A diabetes (T1DM) 3 seems to result from a cell-mediated autoimmune process initiated by yet Cited by: The loss of immune tolerance, increased antigenic load, excess T cell help, defective B cell suppression, and shifting of T helper 1 (Th1) to Th2 immune responses lead to B cell hyperactivity and the production of pathogenic autoantibodies.

10 Autoantibodies and Systemic Autoimmune Diseases (Karsten Conrad and Michael Bachmann). Characteristics and Classification of Systemic Autoimmune Diseases. Distinguishing Features of Systemic Autoimmune Disease-Specific Autoantibodies.

Autoantibodies as Diagnostic and/or Prognostic Markers in Systemic Autoimmune Diseases. The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal by: Publisher Summary.

This chapter describes experimental autoimmune uveoretinitis (EAU) in the rat and the mouse. EAU is a prototypic T-cell-mediated autoimmune disease that targets the neural retina and related tissues.

A unique advantage of the EAU model is that it permits direct visual inspection of disease development and progression. Since publication of the 4th Edition of The Autoimmune Diseases inthe understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened.

This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune Book Edition: 5.

This has only been examined in mice so far, but the researchers now want to use the confetti model to look at how B cell production of autoantibodies is regulated and gets sped up.

Eventually, blocking the germinal centres in some way could put a break in the vicious cycle that autoimmune diseases create. There is, therefore, a growing body of thought to suggest that disrupted B cell activation and/or autoantibody production/clearance could be playing a key role in most autoimmune diseases and that greater understanding of these pathways could be.

The dysfunction may be due to problems in antibody production, impaired cell-mediated immunity, a combined type of antibody/cellular deficiency, impaired phagocytosis, or complement deficiency. Immune system disorders may result in recurrent and unusual infections, or inflammation and dysfunction of the body's own tissues.

The second proposes that autoantibody production results from a generalized process of antigen-independent polyclonal B cell activation 3,4. Several years ago, we suggested a synthesis of these ideas: that polyclonal activation initiated autoantibody production while autoantigenic stimulation perpetuated the process by: 6.

Additional Physical Format: Online version: Boitard, Christian, B cells and autoantibody production in autoimmune diseases. New York: Chapman & Hall ; Austin. Among these B cell subsets self-reactive B cell clones are frequently detected, and may well contribute to autoantibody production and autoimmune disease [ ].

Recent evidence, however, also implicates a role for ‘conventional’ B2 cells in. B Cells Producing Pathogenic Autoantibodies. the role of B cells in autoimmune disease was thought to be predominantly limited to the production of autoantibodies.

Abnormalities in B-cell. However, when introduced into mouse strains other than MRL, the mutated Fas gene did not result in significant autoantibody production associated with florid autoimmune disease.

B cells responsible for autoantibody production also occur in autoimmune disease-prone strains not mutated at Fas/FasL; in fact, the majority of autoimmune diseases in Cited by: Autoimmune disease can result from abnormal B cell recognition of self-antigens followed by the production of autoantibodies.

Autoimmune diseases where disease activity is correlated with B cell activity include scleroderma, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes, post-infectious IBS, and rheumatoid arthritis. Autoimmunity in Cancer. B cell–associated autoimmune responses are frequently found in many tumor types.

A broad spectrum of autoantibodies is found to be associated with certain manifestations of paraneoplastic syndromes, either as only markers or as direct mediators ().Whether autoimmune diseases are associated with increased or reduced risk of cancer is Cited by:   In systemic lupus erythematosus (SLE), and perhaps other autoantibody-mediated diseases, oestrogen seems to increase the risk of disease in genetically predisposed women by targeting key immune Cited by: The immune system’s ability to distinguish self from nonself is essential for initiating host defense against microbial antigens and protection of self-antigens from autoimmune-associated destruction.

Virus infections have been implicated in the initiation of multiple human autoimmune diseases. This chapter aims to summarize the main principles for some specific viral Author: Subuhi Sherwani, Mushtaq Ahmed Khan, Mohammed SulimanAlmogbel.

Autoantibody-secreting B cells and memory B cells that continuously generate autoantibodies are also created, setting the body up for ongoing attacks, chronic inflammation and -- over time. One common feature of autoimmune diseases like systemic lupus erythematosus (SLE) is the presence of high titers of self-reactive antibodies.

These result in immune complexes, inflammation, and tissue pathology. Consequently, the checkpoints that normally keep immunoglobulin G (IgG)–positive autoreactive B cells in check are of intense Cited by: 9. The cell types that would be present in a B cell clone include B-Memory Cells, which are responsible for immunological memory, and plasma cells which are antibody producing 'factories'.

Describe the specific roles of helper, cytotoxic and regulatory T cells in cell-mediated immunity. The immune mechanisms implicated in the development of autoimmune diseases have been categorized into two broad sets of diseases: one set in which the pathological process is driven mainly by T cells and the other in which the humoral B response mainly mediates the disorder by producing autoantibodies that are able to bind tissue self Cited by:   Since publication of the Third Edition inthe understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened.

This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune. The thyroid-stimulating immunoglobulin that acts like thyroid-stimulating hormone and causes Graves disease is an antibody to the _____.

thyroid-stimulating hormone receptor For a transplant to have the best chances of avoiding rejection, the genes coding for the ________ molecules should be closely matched between donor and recipient.

Dear Colleagues, Autoantibodies in autoimmune disease can either present an epiphenomenon or can be active players in disease. While epiphenomenal autoantibodies are the result of an upstream event and have no clear effect on disease development, they can be useful to predict disease and as they reflect the underlying immune response.

B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells.

In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasmablasts/plasma cells in Cited by:   In an autoimmune disease, the body’s immune system mistakenly attacks its own healthy cells.

Exactly how autoantibody-producing B-cells develop has been something of a mystery. Indeed, there are several “quality control” steps in B-cell development that should preclude autoantibody production.

If those steps are working properly, the B-cells that make 5/5(2). Autoantibodies are antibodies (immune proteins) that mistakenly target and react with a person's own tissues or organs.

One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self.". Usually the immune system is able to discriminate between foreign substances ("non-self") and the body’s own cells.

Treatment with the combination of anti-CD antibody and CpG resulted in increased IL-6 and IL secretion and natural autoantibody production of B cells. Our results support the role of CD in the induction of natural autoantibody production, possibly by NS B cells, and suggest an imbalance between the pathologic and natural autoantibody Author: Szabina Erdő-Bonyár, Judit Rapp, Tünde Minier, Gábor Ráth, József Najbauer, László Czirják, Péter Né.

Regulatory B cells (Bregs or B reg cell) represent a small population of B cells which participates in immunomodulations and in suppression of immune responses. These cells regulate the immune system by different mechanisms. The main mechanism is a production of anti-inflammatory cytokine interleukin 10 (IL).

The regulatory effects of Bregs were described in. Each color represents a specific B cell antibody clone. The B cells battle within germinal centers to produce the most effective antibody for a given antigen. Credit: Carroll lab. In these germinal centers, B cells battle each other to create the best antibody for the job of neutralizing the detected threat.

HEALING AUTOIMMUNE DISEASE Dr Sandra Cabot and naturopath Margaret Jasinska give the reader a step by step plan for healing autoimmune disease, reducing inflammation, alleviating symptoms and halting autoantibody production, thereby stopping tissue destruction.

This book offers a medically proven approach to assisting immune system disorders.The cause is generally unknown.

Some autoimmune diseases such as lupus run in families, and certain cases may be triggered by infections or other environmental factors. Some common diseases that are generally considered autoimmune include celiac disease, diabetes mellitus type 1, Graves' disease, inflammatory bowel disease, multiple sclerosis, psoriasis, Medication: Nonsteroidal anti-inflammatory.

Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are Author: Yuhan Gao, Haiqiang Jin, Ding Nan, Weiwei Yu, Jianhua Zhang, Ying Yang, Ruiqin Hou, Ranran Qin, Hong.